EBNA1BP2 (EBNA1 binding protein 2) is a nucleolar protein that plays an essential role in ribosome biogenesis, specifically required for processing of the 27S pre-rRNA [UniProt]. The protein functions as a dynamic scaffold component in the nucleolus, facilitating ribosomal large subunit biogenesis 1. EBNA1BP2 localizes to the nucleolus and demonstrates dynamic behavior through fluorescence recovery after photobleaching analysis, suggesting its active involvement in ribosome assembly processes 1. The protein has been identified as commonly overexpressed across multiple solid tumor types, including carcinomas of the prostate, breast, lung, ovary, colon, pancreas, stomach, bladder, liver, and kidney 2. Clinically, EBNA1BP2 expression correlates with disease susceptibility and progression in various pathological contexts. It has been identified as a hub susceptibility gene for COVID-19 in lung adenocarcinoma patients, with expression levels significantly correlated with immune cell infiltration 3. Additionally, EBNA1BP2 appears as a downregulated gene in sepsis-induced myopathy, suggesting involvement in muscle dysfunction pathways 4. The protein's association with metabolic processes and its altered expression in gastritis patients further indicates broader roles in cellular homeostasis 5.