WDR55 (WD repeat domain 55) is a nucleolar protein that functions as a modulator of ribosomal RNA (rRNA) synthesis and plays a central role during organogenesis. The protein localizes to the nucleolus and nucleoplasm, where it participates in rRNA processing. WDR55 belongs to the WD repeat domain-containing protein family, which are characterized by their ability to serve as scaffolding proteins in various cellular complexes. Recent structural studies have demonstrated that WDR55 can bind small molecules with modest affinity (KD values in the 3-20 µM range), displaying enantioselective binding properties that have been characterized through X-ray crystallography 12. The enantioselective binding mechanisms observed for WDR55 ligands suggest potential druggability of this protein target. However, information regarding disease relevance and specific clinical significance of WDR55 dysfunction is currently insufficient based on available literature. Further research is needed to elucidate whether WDR55 dysregulation contributes to disease pathology and whether its modulation of rRNA synthesis has implications for developmental disorders or other human diseases.