CIRBP (cold inducible RNA binding protein) is a stress-responsive mRNA-binding protein that plays critical roles in cellular protection and gene regulation. The protein functions primarily by binding to 3'-untranslated regions (3'-UTRs) of target mRNAs to enhance their stability and regulate translation 12. CIRBP demonstrates remarkable protective functions in DNA repair mechanisms, with bowhead whale CIRBP showing enhanced capacity for both non-homologous end joining and homologous recombination repair, contributing to exceptional longevity and cancer resistance 34. In pathological contexts, CIRBP exhibits protective effects against neuronal ferroptosis by stabilizing mitochondrial ferritin (FTMT) mRNA, thereby preventing iron overload-induced cell death 1. The protein also plays a role in iron homeostasis through regulation of the hepcidin pathway via BMPER signaling 2. Clinically, CIRBP expression is associated with cardioprotection during hypothermic conditions, with chr19 hypoxia leading to promoter hypermethylation and reduced CIRBP expression 5. In breast cancer, CIRBP is upregulated and correlates with HIF1α expression and tumor angiogenesis 6. These findings establish CIRBP as a multifunctional protein essential for cellular stress responses, DNA repair, and metabolic homeostasis.