CNOT7 is a catalytic subunit of the CCR4-NOT deadenylase complex with 3'-5' poly(A) exoribonuclease activity 12. As a core component of this major mRNA deadenylase, CNOT7 regulates bulk mRNA degradation, miRNA-mediated repression, and translational repression during initiation 123. Its function is partially redundant with CNOT8 4, and it associates with BTG family proteins to support their anti-proliferative activity 15. CNOT7 can be recruited to target mRNAs through RNA-binding proteins like tristetraprolin and MEX3C to facilitate decay 67. Functionally, CNOT7 regulates expression from diverse mRNA positions, demonstrating through-space functional proximity 8. Dysregulation of CNOT7 drives cancer progression across multiple contexts: elevated expression promotes glioma progression via IL6-JAK-STAT3 and NF-κB pathways 9, ovarian cancer via AKT signaling 10, and colorectal cancer radiotherapy resistance through TRIM21/XRCC6-mediated DNA repair 11. Conversely, CNOT7 knockdown reduces lipid deposition in nonalcoholic fatty liver disease 12. These findings position CNOT7 as both a critical mRNA stability regulator and potential therapeutic target.