COLEC11 (collectin kidney-1) is a calcium-dependent pattern recognition lectin that functions in innate immunity, complement activation, and developmental processes. As a soluble C-type lectin, COLEC11 recognizes glycoproteins and carbohydrates on both pathogens and self-antigens, including high-mannose oligosaccharides with terminal alpha-1,2-linked mannose epitopes and fucosylated glycans 1. In innate immunity, COLEC11 binds non-self microbial sugars and activates the complement lectin pathway through MASP recruitment, contributing to antimicrobial defense 21. The protein also participates in clearing apoptotic cells by binding surface DNA in a calcium-independent manner and triggering complement activation 1. During embryogenesis, COLEC11 serves as a guidance cue for neural crest cell migration and other developmental processes 34. Functionally, COLEC11 is expressed by matrix cancer-associated fibroblasts in tumor microenvironments and associates with distinct immune cell phenotypes in metastatic lesions 5. Clinically, mutations in COLEC11 cause 3MC syndrome, characterized by craniofacial abnormalities and developmental defects 6. Additionally, COLEC11 genetic variants influence susceptibility to infectious diseases like Chagas disease through synergistic interactions with MASP2 7.