CORO1A encodes coronin 1A, a crucial actin-binding protein that regulates cytoskeletal organization and cell motility. The protein functions as a component of the actin cytoskeleton in highly motile cells, mediating plasma membrane invagination and protrusion formation during cell locomotion 1. CORO1A plays essential roles in neuronal morphogenesis, where it localizes to growth cones and filopodial structures, mediating responses to the axon guidance cue netrin-1 and collaborating with TRIM67 for proper axon turning, branching, and corpus callosum development 2. In immune contexts, CORO1A is associated with T-cell migration and thymic egress, with mutations linked to autoimmune/immunodeficiency syndromes 1. The protein demonstrates disease relevance in multiple contexts: it serves as a hub biomarker in post-transplant renal fibrosis with positive correlation to immune cell activity 3, shows differential expression in acute lung injury models 4, and functions as a transcription factor in immune-high triple-negative breast cancer subtypes 5. Additionally, CORO1A represents a therapeutic target, as molecular glue degraders like Aurovertin B can promote its neddylation-mediated degradation for cancer treatment 6. The protein also associates with lipid droplets in macrophage foam cells, potentially regulating lipophagy and cholesterol efflux 7.