CORO2B (coronin 2B) is a WD40-domain containing actin-regulating protein that plays a specialized role in cytoskeletal organization, particularly in podocytes and neurons. Functionally, CORO2B localizes to the ventral actin cytoskeleton and focal adhesions, where it regulates actin filament organization and modulates stress responses 1. The protein recruits cofilin (CFL1) to focal adhesions, enabling cytoskeletal plasticity and adaptation to mechanical forces 1. In renal pathology, CORO2B expression is significantly downregulated in diabetic nephropathy patients 2. While CORO2B is not essential for normal glomerular filtration barrier development, it modulates podocyte foot process reorganization under pathological stress, with CORO2B knockout podocytes showing partial protection from protamine sulfate-induced foot process effacement 2. CORO2B demonstrates brain-specific super-enhancer regulation, correlating with strong neuronal expression 3. Clinically, CORO2B shows relevance to multiple disease contexts. It was identified as a component of an 11-gene E3 ubiquitin ligase signature predicting colon cancer prognosis 4, and as a differentially methylated gene in Alzheimer's disease patients 5, where altered methylation may affect cell cycle and TGF-beta signaling pathways. CORO2B has also been proposed as a candidate ciliary gene in ciliopathy-like phenotypes 6.