CORO6 (Coronin 6) is an actin-binding protein containing a conserved WD40 repeat domain that regulates cytoskeletal organization through interactions with F-actin and the Arp2/3 complex 1. The protein functions in actin filament binding and organization at the plasma membrane [GO annotations]. CORO6 plays significant roles in multiple cancer contexts: in osteosarcoma, elevated CORO6 promotes cell proliferation, migration, and invasion via Wnt/β-catenin signaling and glycolysis activation, with METTL3/YTHDF1-mediated m6A modification stabilizing CORO6 mRNA 1. In skeletal muscle, CORO6 undergoes Rbm24-regulated alternative splicing during myogenic differentiation, controlled by microRNA-222 2. CORO6 serves as a biomarker in cardiac pathology, being detectable in circulating cell-free DNA from myocardial infarction patients via digital droplet PCR 3. Additionally, CORO6 appears as a candidate gene in oral squamous cell carcinoma lymph node metastasis prediction 4 and shows epigenetic inactivation through promoter methylation in renal cell carcinoma and age-related methylation changes in breast cancer tissues [PMID:21132003; 58]. These findings suggest CORO6 functions both as an oncogenic driver in some malignancies and as an epigenetically regulated gene in cancer development.