CPPED1 is a calcineurin-like metallophosphoesterase that functions as a serine/threonine protein phosphatase within the PI3K-AKT signaling pathway 1. The protein dephosphorylates AKT1 and PAK4, key components of cell survival and proliferation signaling 1. CPPED1 also inhibits glucose uptake in adipocytes; knockdown of CPPED1 increases expression of glucose metabolism genes (GLUT4, adiponectin) and enhances insulin-stimulated glucose uptake 2. In reproductive biology, CPPED1 expression decreases during spontaneous term labor, regulated by miR-371a-5p, and this down-regulation is associated with inflammation and parturition timing 34. CPPED1 polymorphisms correlate with pregnancy duration 4. Clinically, CPPED1 dysregulation is implicated in multiple pathologies. In laryngeal squamous cell carcinoma, reduced CPPED1 (via circCDK1-mediated m6A modification blocking) activates PI3K-AKT signaling to promote metastasis 5. A CPPED1 neoantigen (R228Q) was identified in colorectal cancer 6. CPPED1 is upregulated in tears of Alzheimer's disease patients, suggesting potential biomarker utility in neurodegeneration 7. CPPED1 was identified as a NET-related prognostic gene in glioblastoma 8.