CPTP (ceramide-1-phosphate transfer protein) is a lipid transfer protein that mediates the intracellular transport of ceramide-1-phosphate (C1P) between organelle membranes, particularly from the Golgi apparatus to specific cellular sites through a non-vesicular mechanism 1. The protein exhibits substrate specificity, preferentially binding phosphoceramides with saturated C16:0 or monounsaturated C18:1 aliphatic chains while showing reduced efficiency with longer chain variants. CPTP's transfer activity is regulated by phosphoinositides, particularly PI-(4,5)P2 and PI-4P, which enhance its function through specific di-arginine motifs that serve as membrane targeting sites 2. The protein plays crucial roles in cellular homeostasis by regulating autophagy, inflammasome-mediated IL-1β and IL-18 processing, and pyroptosis 1. In disease contexts, CPTP is highly expressed in pancreatic cancer and promotes tumor cell growth and metastasis via sphingolipid metabolite ceramide and PI4KA/AKT signaling pathways 3. This makes CPTP a potential biomarker for poor prognosis and a promising therapeutic target. The protein's involvement in inflammation regulation and sphingolipid homeostasis positions it as an important mediator in various pathological processes including cancer progression and inflammatory diseases.