GLTP (glycolipid transfer protein) is a small, 24 kDa soluble protein that accelerates the intermembrane transfer of various glycolipids in vitro 1. The protein exhibits strict specificity for glycolipids with beta-linked initial sugar residues to the hydrophobic lipid backbone, encompassing both sphingoid- and glycerol-based glycolipids, but does not transfer phospholipids or cholesterol 12. GLTP functions through a unique conformational architecture termed the 'GLTP fold,' which defines it as the prototypical member of the GLTP superfamily 1. The protein binds glycolipids in a 1:1 stoichiometric ratio and participates in transfer reactions through a glycolipid-GLTP intermediate complex 2. In humans, GLTP is encoded by a single active gene located on chromosome 12 (12q24.11), with gene expression regulated by Sp1 and Sp3 transcription factors and modulated by the bioactive sphingolipid ceramide 34. While GLTP's biochemical properties are well-characterized, its precise biological role remains enigmatic, though evidence suggests involvement in sphingolipid homeostasis and potential roles in cellular stress responses 15.