GLTPD2 is a glycolipid transfer protein domain-containing protein that belongs to the GLTP superfamily, characterized by a unique all-α-helical 'sandwich' architecture capable of binding and transferring glycosphingolipids, particularly ceramide-1-phosphate 1. The protein functions in intermembrane lipid transport within the cytosol, with documented ceramide 1-phosphate binding and transfer activities 1. GLTPD2 represents an evolutionarily-modified GLTP-fold with altered sphingolipid specificity compared to canonical GLTP members 1. Genomic studies have identified GLTPD2 as a lipid-associated locus with significant clinical relevance. GLTPD2 variants associate with specific lipid species and demonstrate independent association with cardiovascular disease (CVD) risk 2. In the Amish founder population, a rare-population enriched variant (GLTPD2_rs536055318) showed novel associations with sphingolipids 3. Beyond lipid metabolism, GLTPD2 expression is dysregulated in irritable bowel syndrome, showing negative correlation with dysbiotic microbiota genera 4, and emerges as a progression-related gene in chr17 kidney disease risk prediction models 5. Mechanistically, GLTPD2's role in sphingolipid homeostasis regulation may influence inflammatory and metabolic pathways relevant to multiple disease states 1.