CRYBA2 encodes β-crystallin A2, a structural protein that serves as a dominant component of the vertebrate eye lens 1. The protein belongs to the β/γ-crystallin superfamily and is characterized by four Greek key motifs, with each motif encoded by individual exons 1. CRYBA2 is localized on human chromosome 2-q36 and plays a critical role in lens development and transparency 2. The gene exhibits high expression during early lens development, as demonstrated in zebrafish models 3. Multiple studies have identified CRYBA2 mutations as causative factors in autosomal dominant congenital cataracts, including missense mutations such as p.Val50Met, p.Tyr75His, and p.Tyr153His 345. These mutations can cause structural destabilization of the βA2-crystallin protein, disrupting hydrogen bond formation and leading to lens opacity 5. The gene shows reduced expression in cataract-related conditions and age-related lens degeneration 67. Clinically, CRYBA2 mutations are associated with Cataract 42 and represent a significant cause of hereditary cataracts, highlighting its importance as a candidate gene for genetic screening in congenital and presenile cataract cases 23.