CRYGC (crystallin gamma C) is a structural protein that serves as a dominant component of the vertebrate eye lens, essential for maintaining lens transparency and visual perception 1. As a member of the crystallin family, CRYGC functions through its structural protein-binding properties within the lens cytoplasm to preserve optical clarity 2. Mutations in CRYGC cause autosomal dominant congenital cataracts through disruption of protein structure. Identified mutations include missense variants (p.Leu90Arg, p.R48H, p.Trp131Arg), nonsense mutations (p.C109X, p.Tyr139X, p.Tyr144X, p.Arg169X), and frameshift mutations that produce various cataract phenotypes ranging from nuclear to pulverulent forms 3456. Structural analyses demonstrate that mutations cause loss of Greek key motifs and increased protein aggregation propensity, particularly with photodamage 46. CRYGC mutations account for approximately 4.1% of autosomal dominant congenital cataract cases in Chinese populations 5. Clinical manifestations vary from isolated cataracts to complex anterior segment dysgenesis including microphthalmia, microcornea, and nystagmus 78. Notably, digenic inheritance with mutations in multiple cataract genes produces more severe phenotypes than single-gene variants 7. CRYGC expression levels correlate with specific cataract morphologies, particularly anterior capsular changes 1.