DAZ2 is an RNA-binding protein essential for male spermatogenesis, functioning primarily through 3'-UTR-mediated mRNA regulation. The protein acts as a translation regulator, binding to mRNA 3' untranslated regions to modulate translational initiation and mRNA stability 1. DAZ2 exists in a four-copy gene family (DAZ1-4) on the Y chrY's AZFc region; deletions of specific DAZ copies are associated with male infertility. Individual DAZ2 deletions occur frequently in both fertile and infertile populations, but combined deletion of DAZ2 and DAZ4 significantly associates with male infertility 2. DAZ1/DAZ2 cluster deletions represent a particularly high-risk factor for severe oligozoospermia and azoospermia across multiple populations 3, 4, 5. In contrast, DAZ3/DAZ4 deletions show minimal fertility impact 5. DAZ2's clinical significance is underscored by its potential therapeutic application: overexpression of DAZ2 alongside DAZL and BOULE successfully reprograms human Sertoli cells into functional spermatogonial stem cells with self-renewal capacity, offering promising approaches for male infertility treatment 1. Genetic screening for DAZ1/DAZ2 deletions is recommended in severely oligozoospermic patients before assisted reproduction procedures.