DCC (Deleted in Colorectal Cancer) encodes a transmembrane receptor protein of the immunoglobulin-CAM family that serves dual functions in neural development and tumor suppression 1. As a netrin-1 receptor, DCC mediates axon guidance by promoting chemoattraction of commissural axons to the midline during nervous system development 2. The receptor's cytoplasmic tail contains a conserved WAVE regulatory complex-interacting receptor sequence (WIRS) motif that is essential for netrin-1-mediated axon guidance through actin dynamics regulation 3. DCC can also mediate axon repulsion when associated with UNC5 proteins 2. Beyond neural development, DCC functions as a tumor suppressor gene, with frequent loss of expression observed in colorectal cancers and other malignancies including lung cancer and hematological malignancies 145. The protein shows an inverse relationship between differentiation and tumorigenesis, being expressed in differentiated intestinal cells but lost in dedifferentiated tumors 1. Genetic variants in DCC are associated with congenital mirror movements, with one variant (R1343H) disrupting the DCC-WAVE regulatory complex interaction and impairing axon guidance 3. Additionally, DCC-mediated netrin-1 signaling appears to play protective roles in precancerous lesions by modulating sympathetic neuroplasticity 6.