DCTN6 (dynactin subunit 6) is a component of the dynactin complex that activates the molecular motor dynein for processive transport along microtubules 1. The protein localizes to centrosomes, the dynactin complex, and cytosol, where it participates in mitotic spindle organization and dynein-mediated cargo transport [GO annotations]. Mechanistically, DCTN6 interacts with reticulon 3 (RTN3) to mediate tubular endoplasmic reticulum trafficking in axons; DCTN6 deficiency impairs this trafficking, leading to abnormal ER accumulation and dystrophic neurite formation in aging brains 1. DCTN6 expression also plays roles in meiotic cell division, with aging modulating its expression in oocytes 2. Clinically, DCTN6 demonstrates prognostic significance in multiple malignancies. In cutaneous melanoma, high DCTN6 expression associates with favorable overall survival 3, and the lncRNA SPRIGHTLY regulates DCTN6 expression to promote melanoma growth 4. Similarly, in low-grade gliomas, elevated DCTN6 expression correlates with improved survival outcomes 5. In ovarian cancer, DCTN6 serves as a glycosylation-related prognostic biomarker predicting patient outcomes and immune microenvironment composition 6. These findings suggest DCTN6 functions as a tumor suppressor across multiple cancer types.