RMDN1 (regulator of microtubule dynamics 1) is a protein that functions in microtubule organization and spindle dynamics. Located on chromosome 8, RMDN1 localizes to centrosomes, mitochondria, and the cytoplasm, where it regulates mitotic spindle microtubules and their attachment to kinetochores [GO annotations]. Beyond its canonical role in cell division, RMDN1 has emerged as a mitochondria-related gene with significant neuropsychiatric associations. Genetically elevated RMDN1 levels are associated with decreased ADHD risk, with a one standard deviation increase linked to a 12% risk reduction (OR = 0.88, 95% CI: 0.83-0.94) 1. RMDN1 also demonstrates protective associations with cognitive outcomes; increased plasma RMDN1 levels show positive causal relationships with intelligence, fluid intelligence scores, and cognitive performance through Mendelian randomization analysis 2. Additionally, RMDN1 exhibits causal associations with reproductive aging, colocalizing with age at menarche in proteomic studies 3. In cancer biology, RMDN1 is downregulated in papillary thyroid carcinoma and identified as a differentially methylated hub gene with potential diagnostic value (AUC > 90%), suggesting aberrant DNA methylation may underlie reduced expression in thyroid malignancy 4. These findings indicate RMDN1 functions beyond mitochondrial dynamics as a biomarker for neurodevelopmental health and oncological processes.