DGAT2L6 is an X-linked diacylglycerol acyltransferase that catalyzes the esterification of fatty acyl-CoA with glycerol substrates. The enzyme exhibits preferential activity toward oleate and can utilize 1-monoalkylglycerol as an acyl acceptor to synthesize monoalkyl-monoacylglycerol, but lacks wax synthase activity 1. Phylogenetically, DGAT2L6 belongs to the acylglycerol acyltransferase superfamily and likely arose prior to the divergence of marsupial and eutherian mammals 2. The gene is broadly expressed across human tissues and plays roles in lipid metabolism, including processes related to lipid storage and cytoprotection 1. At the epigenetic level, DGAT2L6 harbors a CpG site (cg27064949) that exhibits strong age-correlation in blood methylation patterns, suggesting potential utility in chrX age prediction models 3. While DGAT2L6 is catalogued in disease databases for associations including breast cancer and acute lymphoblastic leukemia, the retrieved abstracts do not establish mechanistic links between DGAT2L6 dysfunction and these conditions. The gene's precise physiological role in disease pathogenesis remains to be elucidated.