DISP3 (dispatched RND transporter family member 3) is a sterol-sensing domain-containing protein that functions as a critical regulator of neural stem cell fate decisions and cholesterol homeostasis 1. In neural tissue, DISP3 promotes proliferation of neural progenitor cells while suppressing their differentiation 2. At the molecular level, DISP3 localizes to the endoplasmic reticulum where it colocalizes with cholesterol and influences cellular cholesterol distribution 1. DISP3 expression is dynamically regulated during neural differentiation, with decreased expression observed upon differentiation into astrocytes, neurons, and oligodendrocytes, suggesting its role in maintaining neural stem cell identity 3. DISP3 likely participates in the Hedgehog signaling pathway as a member of the Dispatched family of lipid-modified protein transporters 4. Clinically, DISP3 variants have been associated with multiple phenotypes: a protective polymorphism (rs2076469) was identified in congenital Zika syndrome susceptibility 5, and PTCHD2 (DISP3) variants were significantly associated with spherical equivalent and refractive error in ocular studies 6. Additionally, DISP3 variants showed association with tanning dependence 7. These findings suggest DISP3's involvement in thyroid hormone-regulated cholesterol metabolism and neurodevelopmental processes.