DNAJC13 (DnaJ heat shock protein family member C13) is an endosome-associated protein that functions as a co-chaperone of HSP70, playing critical roles in intracellular membrane trafficking and protein homeostasis 1. The protein regulates endosomal membrane dynamics, facilitating cargo transport from early endosomes to both recycling and late endosomes, and coordinates with the WASH complex and retromer machinery to control SNX1 dynamics on endosomal membranes 2. DNAJC13 positively modulates macroautophagy, a lysosomal degradative pathway essential for cellular quality control 2. Disease-associated mutations, particularly the N855S variant, have been identified in Parkinson's disease and essential tremor 34. The PD-linked N855S mutant exhibits reduced protein stability and loss-of-function deficits, impairing autophagic activity and causing abnormal α-synuclein accumulation in endosomal compartments, ultimately promoting dopaminergic neurodegeneration 25. These findings suggest DNAJC13 mutations contribute to PD pathogenesis through disrupted endosomal trafficking and autophagy, highlighting the critical role of endosomal pathway impairment in neurodegeneration.