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0 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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MRC2
mannose receptor C-type 2
Chromosome 17 · 17q23.2
NCBI Gene: 9902Ensembl: ENSG00000011028.14HGNC: HGNC:16875UniProt: Q9UBG0
83PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
Receptor
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
collagen bindingfocal adhesionmembraneosteoblast differentiationAbdominal Aortic Aneurysmaneurysmaortic aneurysmtype 2 diabetes mellitus
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

mannose receptor C-type 2

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
Abdominal Aortic AneurysmOpen Targets
0.47Moderate
aneurysmOpen Targets
0.41Moderate
aortic aneurysmOpen Targets
0.41Moderate
type 2 diabetes mellitusOpen Targets
0.33Weak
hypertensionOpen Targets
0.33Weak
coronary artery diseaseOpen Targets
0.31Weak
migraine disorderOpen Targets
0.31Weak
musculoskeletal system diseaseOpen Targets
0.27Weak
neoplasmOpen Targets
0.11Weak
mathematical abilityOpen Targets
0.09Suggestive
breast cancerOpen Targets
0.08Suggestive
gliomaOpen Targets
0.08Suggestive
cancerOpen Targets
0.08Suggestive
sarcomaOpen Targets
0.08Suggestive
non-alcoholic fatty liver diseaseOpen Targets
0.08Suggestive
Miyoshi myopathyOpen Targets
0.07Suggestive
prostate cancerOpen Targets
0.07Suggestive
hepatocellular carcinomaOpen Targets
0.07Suggestive
atrial fibrillationOpen Targets
0.06Suggestive
glioblastoma multiformeOpen Targets
0.06Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
PLA2R1Protein interaction91%PLAURProtein interaction85%PLAUProtein interaction84%MRC1Protein interaction69%CCDC158Shared pathway33%ZNF25Shared pathway33%
Tissue Expression6 tissues
Ovary
100%
Lung
63%
Heart
52%
Bone Marrow
18%
Liver
5%
Brain
4%
Gene Interaction Network
Click a node to explore
MRC2PLA2R1PLAURPLAUMRC1CCDC158ZNF25
PROTEIN STRUCTURE
Preparing viewer…
PDB5EW6 · 2.29 Å · X-ray
View on RCSB ↗
Constraintⓘ
LOEUFⓘ
0.51Moderately Constrained
pLIⓘ
0.00Tolerant
Observed/Expected LoF0.43 [0.36–0.51]
RankingsWhere MRC2 stands among ~20K protein-coding genes
  • #5,740of 20,598
    Most Researched83
  • #3,144of 17,882
    Most Constrained (LOEUF)0.51 · top quartile
Genes detectedMRC2
Sources retrieved0 papers
Response time—