DNAJC28 is a member of the DnaJ/Hsp40 heat shock protein family located on chromosome 21, functioning as a molecular chaperone involved in protein folding and temperature homeostasis 1. The gene demonstrates functional significance across multiple pathological contexts. In neuroinflammatory disease, DNAJC28 expression is substantially altered in the hippocampus in response to TWEAK activation in neuropsychiatric lupus, suggesting involvement in neuroinflammatory and neurodegenerative processes 2. DNAJC28 shows suggestive genetic associations with sporadic late-onset Parkinson's disease through rare missense variants identified in large case-control studies, implicating molecular chaperone dysfunction in PD pathogenesis 3. The gene plays a role in cold temperature adaptation, with positive selection signals detected in Chinese rhesus macaques enabling rapid thermoregulation in cold environments 1. In cancer biology, DNAJC28 emerged as a mitochondrial-related gene component of a prognostic signature model for colon adenocarcinoma survival prediction 4, and is differentially expressed in macrophages under high-fat diet conditions, linking it to obesity-associated colonic inflammation and tumorigenesis 5. These findings collectively suggest DNAJC28 functions as a stress-response chaperone with relevance to neurodegenerative, inflammatory, and oncological disease mechanisms.