DNASE1L1 (deoxyribonuclease 1 like 1) is a member of the DNase1 family that functions as an endonuclease involved in DNA degradation and cellular metabolism. The protein exhibits deoxyribonuclease I activity and plays a role in DNA catabolic processes 1. Evolutionary analysis reveals that DNASE1L1 co-existed with other DNase1 family members in jawless fish and acquired a GPI-anchor for plasma membrane attachment in bony fishes, facilitating its extracellular function 1. The gene is located on the X chromosome X shows tissue-specific expression patterns 2. DNASE1L1 has been implicated in several disease contexts through genetic association studies. Expression quantitative trait loci (eQTL) analysis identified variants in DNASE1L1 associated with multiple conditions including bilirubin levels, type 1 diabetes, and schizophrenia 3. Alternative splicing events in DNASE1L1 have been identified as prognostic biomarkers in uveal melanoma, with specific splicing patterns associated with patient survival outcomes 45. Additionally, amplifications of DNASE1L1 on chromosome X have been consistently observed in ovarian mature cystic teratomas, suggesting a potential role in tumor formation 6. These findings indicate DNASE1L1's importance in both normal cellular processes and disease pathogenesis.