DNTTIP2 (deoxynucleotidyltransferase terminal interacting protein 2) is a multifunctional protein that plays essential roles in ribosome biogenesis and cellular proliferation. As part of the small subunit (SSU) processome, DNTTIP2 participates in the early assembly of the small eukaryotic ribosomal subunit in the nucleolus, where it works with other biogenesis factors to facilitate RNA folding, modifications, and processing of pre-ribosomal RNA 1. The protein also regulates transcriptional activity and may function as a chr1 remodeling protein 23. DNTTIP2 demonstrates significant disease relevance across multiple cancer types. In pancreatic cancer, DNTTIP2 depletion induces cell cycle arrest through decreased expression of SATB1 and CDK6, indicating its role in cancer cell proliferation 4. The gene has been identified as a susceptibility locus for early-onset intracerebral hemorrhage 5 and shows altered expression in hepatocellular carcinoma, where it correlates with immune infiltration patterns and poor prognosis 67. DNTTIP2 is also differentially expressed in pediatric acute myeloid leukemia 8 and appears in cuproptosis-related gene signatures associated with various pathological conditions 910. These findings suggest DNTTIP2 as a potential therapeutic target and diagnostic biomarker across multiple disease contexts.