DOK5 is a member of the DOK (downstream of tyrosine kinase/docking protein) family that functions as an enzymatically inert adaptor protein, providing a scaffolding platform for multimolecular signaling complexes 1. DOK5 serves as a substrate for TrkB and TrkC neurotrophin receptors, interacting through its PTB domain with the NPQY motif in a kinase-activity-dependent manner and competing with N-shc for the same binding site 2. The protein plays crucial roles in neurotrophin-induced MAPK pathway activation and is essential for NT-3 signaling that prevents TrkC-induced apoptosis by regulating caspase-3 activity 23. DOK5 expression is upregulated during osteoblast differentiation and regulates bone cell proliferation and differentiation through canonical Wnt/β-catenin signaling 4. The protein is also involved in fibrotic processes, being upregulated by IGFBP-5 in a MAPK-dependent manner and contributing to dermal thickening 5. Clinically, DOK5 variants show associations with type 2 diabetes and obesity susceptibility 6, and the gene has been identified as a potential diagnostic biomarker for intracranial aneurysms 7. These findings establish DOK5 as a versatile adaptor protein involved in neuronal survival, bone metabolism, fibrosis, and metabolic disorders.