DPP10 (dipeptidyl peptidase like 10) is a voltage-gated potassium channel regulator that lacks mammalian dipeptidyl peptidase activity 1. Its primary function involves promoting cell surface expression of the potassium channel KCND2 and modulating its gating characteristics 2. Beyond KCND2, DPP10 serves as a regulatory subunit for cardiac Nav1.5 sodium channels, where increased expression in heart failure reduces peak sodium current while increasing window current, potentially promoting arrhythmias 3. Mechanistically, DPP10 acts as an ancillary subunit forming complexes with voltage-gated potassium channels to control their gating properties 4. It shifts voltage-dependent activation and inactivation curves, accelerates recovery from inactivation, and reduces channel inactivation kinetics 3. Clinically, DPP10 polymorphisms are recognized asthma susceptibility loci 5. Genetic variants in DPP10 associate significantly with asthma-related traits in Han Chinese populations, including total IgE levels and peripheral blood eosinophil percentages 6. Additionally, DPP10 has emerged as a loneliness-associated switch gene overlapping with genetic risk factors for Alzheimer's disease 7. These findings suggest DPP10's multifaceted role in regulating ion channel function and contributing to immune-mediated and neurodegenerative disease susceptibility.