DPYSL2 (dihydropyrimidinase-like 2) encodes CRMP2, a microtubule-stabilizing protein essential for neuronal development and function. The protein plays critical roles in neurogenesis, axonal growth, and cellular projection formation 1. DPYSL2 is highly expressed in sensory neurons including nociceptors and dorsal root ganglion neurons, where it contributes to axonal growth and regeneration 2. The gene generates multiple isoforms with distinct functions - knockout of the DPYSL2-B isoform reduces dendritic length by up to 58% and disrupts mTOR signaling pathways 1. DPYSL2 localizes to centrosomes where it promotes ciliogenesis through interaction with USP21, which prevents its proteasomal degradation via deubiquitination 3. The protein is implicated in psychiatric disorders, with genetic variants associated with schizophrenia and alcohol dependence 45. In disease contexts, DPYSL2 dysfunction affects cellular projections, immune function, calcium signaling, and cholesterol biosynthesis 1. The gene also shows altered expression in cancer metastasis, suggesting broader roles in cellular migration and invasion 6. DPYSL2's involvement in mTOR signaling and neurodevelopmental processes makes it a key player in both normal brain function and psychiatric pathogenesis.