PLXNA2 encodes plexin A2, a transmembrane receptor protein that serves as a coreceptor for semaphorin guidance molecules, particularly SEMA3A and SEMA6A 1. The protein plays critical roles in neurodevelopment through axon guidance, cell migration, and cytoskeletal remodeling 2. PLXNA2 functions by forming complexes with neuropilins to bind class 3 semaphorins, with its cytoplasmic domain containing a GTPase activating (GAP) domain that is essential for downstream signaling through FARP2 and FYN pathways 3. In human chondrocytes, SEMA3A signaling through plexin A2 increases protein content and suppresses PTH-R1 expression, suggesting roles in skeletal development 1. Disease associations include schizophrenia susceptibility in some populations 4 and autism spectrum disorder, where PLXNA2 variants cause protein mislocalization and reduced interactions with LRRC40 2. In cancer contexts, PLXNA2 promotes glioblastoma cell proliferation and tumor formation through AKT signaling, making it a potential therapeutic target 3. The protein's broad roles in neural development, skeletal biology, and oncology highlight its importance in multiple physiological and pathological processes.