EGFLAM (EGF-like, fibronectin type III and laminin G domains) is a multifunctional extracellular matrix protein with critical roles in retinal synaptic organization and cancer progression. In the retina, EGFLAM (also known as pikachurin) serves as a key mediator of transsynaptic assembly between photoreceptors and bipolar cells, facilitating the interaction between dystroglycan-dystrophin complex and orphan receptor GPR179 1. This function is essential for proper photoreceptor ribbon synapse formation and visual signal transmission, with pathogenic variants causing congenital stationary night blindness (CSNB) characterized by ON-bipolar cell dysfunction 2. The protein's structural organization includes Cache domain recognition sites that enable specific molecular interactions crucial for synaptic alignment 1. Beyond retinal function, EGFLAM exhibits oncogenic properties across multiple cancer types, particularly glioblastoma and gastric cancer, where overexpression correlates with poor prognosis, enhanced cell proliferation, migration, and invasion 345. The oncogenic mechanisms involve PI3K/AKT signaling pathway activation and extracellular matrix receptor interactions 45. EGFLAM expression is also associated with immune cell infiltration and tumor mutation burden, positioning it as both a prognostic biomarker and potential therapeutic target 46.