DUSP10 (dual specificity phosphatase 10) is a MAP kinase phosphatase that negatively regulates p38 MAPK and c-Jun N-terminal kinase (JNK) signaling 1. The enzyme dephosphorylates and inactivates members of the p38 MAPK subfamily (MAPK11/MAPK12/MAPK13/MAPK14) and can also modulate ERK signaling 1. DUSP10 protein stability is enhanced by phosphorylation-mediated post-translational modifications 2. In inflammatory contexts, DUSP10 acts as a critical negative regulator of JNK1 activation. TET2-deficient macrophages show decreased DUSP10 expression due to increased promoter methylation, leading to uncontrolled JNK1 phosphorylation and downstream NLRP3 inflammasome activation, with implications for atherosclerosis progression 3. Clinically, DUSP10 dysfunction is associated with multiple diseases. Genetic variants in DUSP10 correlate with colorectal cancer risk in Han Chinese populations 4, and elevated DUSP10 expression is an independent prognostic indicator of poor survival in lower-grade glioma 5. DUSP10 variants represent a confirmed genetic risk locus for progressive supranuclear palsy 67. Additionally, DUSP10 dysregulation may contribute to systemic lupus erythematosus pathogenesis through T-cell signaling disruption 8.