EFCAB11 (EF-hand calcium binding domain 11) is a calcium-binding protein located on chromosome 14.11 with established roles in protein interactions and calcium signaling. Based on GO annotations, EFCAB11 functions in calcium ion binding and may regulate enzyme activity and microtubule cytoskeleton organization 1. The gene has demonstrated relevance to multiple disease pathways. In neurodegenerative disease, EFCAB11 circular RNA is specifically over-expressed in multiple system atrophy (MSA) brain tissue, particularly in white matter, suggesting involvement in α-synucleinopathy pathology 1. Regarding cardiovascular disease, genetic variants near EFCAB11 (rs4143999) show strong association with carotid plaque presence and area in Dominican families (p=0.00001 and 0.00003 respectively), with replication in the Northern Manhattan Study population 2. In hepatocellular carcinoma (HCC), the rs8013403 SNP within EFCAB11 is significantly associated with reduced HCC risk (OR=0.80, p=1.54×10⁻³) in Chinese populations, and shows genetic interaction with STAT4 variants in HCC susceptibility 3. Additionally, a nonsense variant in EFCAB11 has been identified exclusively in a 22q11.2 deletion carrier with schizophrenia, suggesting involvement in neuropsychiatric disease 4. These findings indicate EFCAB11 contributes to neurodegenerative, cardiovascular, metabolic, and psychiatric disease susceptibility.