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GeneE
2 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
TOGARAM2
TOG array regulator of axonemal microtubules 2
Chromosome 2 Β· 2p23.2
NCBI Gene: 165186Ensembl: ENSG00000189350.14HGNC: HGNC:33715UniProt: B4DLF7
9PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
microtubule bindingmicrotubule cytoskeleton organizationcytoplasmic microtubuleciliumovarian dysfunctiondeafnesshearing loss, autosomal recessivetriple-negative breast cancer
✦AI Summary

Based on limited published evidence, TOGARAM2 is a microtubule-associated protein involved in cilium organization and axonemal microtubule regulation. GO annotations indicate roles in cytoplasmic microtubule binding and microtubule cytoskeleton organization. Recently, TOGARAM2 was identified as a TAZ transcriptional target that promotes cell proliferation, migration, and invasion in HPV18+ cervical cancers 1. Additionally, TOGARAM2 variants have been proposed as a potential cause of autosomal recessive non-syndromic hearing loss, with protein localization to cochlear hair cells 2, suggesting roles in kinociliary function essential for hearing.

Sources cited
1
TOGARAM2 identified as TAZ target gene that mediates TAZ-dependent proliferation, migration, and invasion in HPV18+ cervical cancer cells
PMID: 38987584
2
TOGARAM2 variants associated with autosomal recessive non-syndromic hearing loss; protein localizes to cochlear hair cells
PMID: 38374469
⚠Limited data available β€” This gene has 2 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
ovarian dysfunctionOpen Targets
0.31Weak
deafnessOpen Targets
0.26Weak
hearing loss, autosomal recessiveOpen Targets
0.26Weak
triple-negative breast cancerOpen Targets
0.11Weak
breast carcinomaOpen Targets
0.10Suggestive
goutOpen Targets
0.06Suggestive
luminal A breast carcinomaOpen Targets
0.06Suggestive
cervical cancerOpen Targets
0.04Suggestive
pseudohypoaldosteronism type 2BOpen Targets
0.04Suggestive
pseudohypoaldosteronism type 2DOpen Targets
0.04Suggestive
mood disorderOpen Targets
0.03Suggestive
cervical carcinomaOpen Targets
0.03Suggestive
dental cariesOpen Targets
0.03Suggestive
denturesOpen Targets
0.03Suggestive
Tetralogy of FallotOpen Targets
0.02Suggestive
diabetes mellitusOpen Targets
0.02Suggestive
type 2 diabetes mellitusOpen Targets
0.02Suggestive
hearing lossOpen Targets
0.02Suggestive
acute quadriplegic myopathyOpen Targets
0.01Suggestive
brucellosisOpen Targets
0.01Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
TXNDC9Shared pathway100%MAP7D1Shared pathway100%CGNShared pathway100%CCDC170Shared pathway100%TTLL2Shared pathway100%EFCAB11Shared pathway100%
Tissue Expression6 tissues
Heart
100%
Lung
63%
Bone Marrow
50%
Ovary
22%
Brain
21%
Liver
16%
Gene Interaction Network
Click a node to explore
TOGARAM2TXNDC9MAP7D1CGNCCDC170TTLL2EFCAB11
PROTEIN STRUCTURE
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AlphaFoldAI-predicted Β· UniProt Q6ZUX3
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
1.19LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF0.99 [0.83–1.19]
RankingsWhere TOGARAM2 stands among ~20K protein-coding genes
  • #17,486of 20,598
    Most Researched9
  • #12,499of 17,882
    Most Constrained (LOEUF)1.19
Genes detectedTOGARAM2
Sources retrieved2 papers
Response timeβ€”
πŸ“„ Sources
2
1
The Hippo pathway transcription factors YAP and TAZ play HPV-type dependent roles in cervical cancer.
PMID: 38987584
Nat Commun Β· 2024
1.00
2
Genetic heterogeneity in hereditary hearing loss: Potential role of kinociliary protein TOGARAM2.
PMID: 38374469
Eur J Hum Genet Β· 2024
0.50