ELAPOR1 (endosome-lysosome associated apoptosis and autophagy regulator 1), also known as KIAA1324, is a multifunctional protein with roles in cellular homeostasis and disease regulation. Mechanistically, ELAPOR1 localizes to the trans-Golgi network, endosomes, and secretory vesicles where it recruits clathrin via its YSKL adaptor-binding motif to mediate vesicle trafficking and autophagy 1. In pancreatic β-cells, ELAPOR1 functions as an insulin-binding receptor (inceptor) that directs proinsulin and insulin toward lysosomal degradation, thereby regulating insulin homeostasis 2. ELAPOR1 also suppresses tumor progression across multiple cancer types by inhibiting GRP78-mediated oncogenic signaling and promoting classical/progenitor subtype characteristics in pancreatic ductal adenocarcinoma through metabolic reprogramming 34. Additionally, ELAPOR1 is required for acrosome biogenesis during spermiogenesis, with deficiency causing male infertility 1. Clinically, reduced ELAPOR1 expression associates with poor prognosis in gastric and colorectal cancers 35, and ELAPOR1 protein is notably absent in neurons with pathological TDP-43 in ALS/FTD, suggesting impaired function in neurodegeneration 6. These findings position ELAPOR1 as a potential diagnostic and therapeutic target across metabolic and malignant diseases.