EXOC3L4 (exocyst complex component 3 like 4) is a component of the exocyst complex involved in vesicle trafficking and exocytosis. Based on sequence homology, EXOC3L4 likely functions as part of the exocyst complex, which mediates SNARE binding and exocyst localization 1. The gene is abundantly expressed in endothelial cells during embryonic development, suggesting roles in cardiovascular function 2. EXOC3L4 has emerged as a novel Alzheimer's disease (AD) risk gene. Rare missense variants cluster spatially around the Sec6 domain and associate with AD phenotypes 3. Specifically, rare variants in splicing regulatory elements of EXOC3L4 are significantly associated with reduced global cortical glucose metabolism in AD patients, as measured by FDG-PET imaging 1. This association suggests that splicing variants affecting EXOC3L4 may impair vesicle transport mechanisms critical for neuronal function. Additionally, cadmium exposure-associated differential methylation at EXOC3L4 loci correlates with increased gene expression in placental tissue, linking environmental toxicant exposure to altered EXOC3L4 regulation during fetal development 4. These findings indicate EXOC3L4 functions in vesicle transport pathways relevant to both neurodegeneration and developmental toxicity.