EXOC6 encodes a critical component of the exocyst complex that functions in vesicle docking and exocytosis at the plasma membrane 1. The protein plays essential roles in insulin-stimulated glucose transport by facilitating GLUT4 translocation through its interaction with Rab10-GTP, where knockdown of EXOC6 inhibits GLUT4 translocation in adipocytes 1. In pancreatic β-cells, EXOC6 is crucial for insulin secretion and exocytosis machinery, with silencing leading to impaired insulin secretion, reduced insulin content, and decreased expression of key genes including Ins1, Ins2, Pdx1, Glut2, and Vamp2 2. Disease relevance includes strong associations with type 2 diabetes risk, where genetic variants in EXOC6 (rs947591, rs2488071, rs2488073) show genome-wide significant associations with T2D susceptibility 2. Additional disease associations include gestational diabetes mellitus in Chinese populations 3 and breast cancer risk prediction, where EXOC6 expression serves as a biomarker for cancer development in women with sclerosing adenosis 4. The gene has also been implicated in Alzheimer's disease pathogenesis in APOE4 non-carriers 5 and potentially in optic nerve aplasia through chr10 microdeletions 6.