EXOSC2 is a non-catalytic structural component of the RNA exosome complex, a multisubunit ribonuclease that processes and degrades various cellular RNAs 1. The protein functions in both nuclear and cytoplasmic compartments, participating in RNA processing, surveillance, and degradation pathways 1. EXOSC2 stabilizes the hexameric ring structure of the exosome core complex through interactions with other subunits, serving as a scaffold for catalytic components 1. The protein demonstrates RNA-binding capabilities and interacts with various cellular RNAs, including coding and non-coding species 2. Disease-wise, mutations in EXOSC2 cause a distinct syndrome characterized by retinitis pigmentosa, hearing loss, and mild intellectual disability, differing from other RNA exosomopathies 13. Recent studies reveal EXOSC2's role in viral replication, where reduced expression impedes SARS-CoV-2 replication through interactions with viral RNA polymerase components 45. Additionally, EXOSC2 shows oncogenic properties in breast cancer, promoting tumor progression through Wnt/β-catenin pathway activation, with its expression regulated by m6A methylation modifications 6. The protein's involvement in translation regulation and ribosome biogenesis has been demonstrated through comparative studies of disease-linked mutations 7.