FABP7 (fatty acid binding protein 7) is a brain-type fatty acid binding protein primarily expressed in astrocytes and radial glia that regulates lipid metabolism and transport in the central nervous system. Primary function involves facilitating fatty acid transport to cellular organelles and mediating lipid-dependent signaling 1. During CNS development, FABP7 is required for establishing the radial glial fiber system essential for neuronal migration and cortical layer formation. Mechanistically, FABP7 binds polyunsaturated fatty acids and endocannabinoids, modulating downstream signaling through MEK1/2 phosphorylation and NF-κB-driven inflammatory pathways 23. The protein also regulates glycolytic switching and mitochondrial function, influencing cellular energy metabolism and lipid composition 4. Disease relevance is substantial across multiple conditions. In autism spectrum disorder, FABP7 deficiency causes premature neural differentiation through dysregulation of the FABP7/MEK pathway 2. In Alzheimer's disease, FABP7 is upregulated in astrocytes surrounding amyloid plaques and drives NF-κB-dependent neuroinflammation 3. FABP7 elevation correlates with progressive multiple sclerosis severity and disability 4. In cancer, FABP7 upregulation enables ferroptosis evasion and immunotherapy resistance by reprogramming lipid metabolism 56. Clinically, elevated FABP7 expression predicts poor immunotherapy outcomes and represents a potential therapeutic target across neurodegenerative and malignant diseases 54.