FAM50B is an imprinted gene located at chromosome 6.2 that functions in chr6 organization and protein binding within the nucleus. The gene shows parent-of-origin-specific expression, with paternal allele expression in most tissues except ovary 1. FAM50B originated through retrotransposition from the X chromosome 6 Therians and acquired imprinting during Eutherian evolution 1. Functionally, FAM50B displays genetic redundancy with its paralog FAM50A; co-disruption of both genes reduces cellular fitness in cancer cells and promotes micronucleus formation with transcriptional perturbation 23. FAM50B is associated with multilocus imprinting disturbances (MLID), where epimutations in FAM50B correlate with severe imprinting defects across multiple genomic regions 4. The gene holds clinical significance for male reproductive health, with variants identified in nonobstructive azoospermia patients 5, and FAM50B expression is deregulated in testicular germ cell tumors 1. Recent evidence demonstrates that FAM50B DNA methylation status serves as a quantitative biomarker correlating with reduced intelligence quotient in lead-exposed children, mediated through PI3K-AKT signaling and reactive oxygen species production 6.