FARP2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2) functions as a guanine nucleotide exchange factor (GEF) that activates RAC1 and CDC42 GTPases 1. The protein contains a characteristic N-terminal FERM domain that mediates both membrane localization through phospholipid binding and protein-protein interactions 2. FARP2 plays critical roles in semaphorin signaling and actin cytoskeleton remodeling 3, osteoclast differentiation and podosome assembly 3, and epithelial polarity formation through aPKCι-dependent phosphorylation 1. In the plexin-A2 signaling pathway, FARP2 mediates pro-proliferative effects in glioblastoma-derived cells 4. Disease relevance includes associations with autism spectrum disorder; FARP2 haploinsufficiency contributes to phenotypes in 2q37.3 deletion syndrome 5, and FARP2 downregulation occurs in ASD cases with RERE mutations 6. FARP2 DNA methylation patterns are associated with growth outcomes in children exposed to gestational diabetes 7. Pathogenic variants in FARP2 (rs757978) have been identified as damaging cancer-risk alleles in specific populations 8. These findings suggest FARP2 as a potential therapeutic target in cancer and neurodevelopmental disorders.