SRC encodes a non-receptor protein tyrosine kinase that functions as a central hub in multiple signal transduction pathways regulating cellular proliferation, differentiation, motility, and survival 1. Under normal conditions, SRC activity is suppressed by phosphorylation on its carboxy-terminal tail by CSK kinase, but various cellular stimuli or mutations can activate its endogenous kinase activity 2. SRC activation involves multiple intracellular pathways and can result in morphological changes and cell proliferation 2. The protein shows elevated expression and activity in numerous human cancers, including colon, liver, lung, breast, and pancreatic tumors, with activation documented in upwards of 50% of these malignancies 13. SRC appears to be a critical component of oncogenic processes including proliferation, survival, metastasis, and angiogenesis 4. In neuroblastoma, simultaneous expression of the FAK-Src-Paxillin protein system correlates with unfavorable prognosis and increased mortality 5. SRC can also interact with AMPK signaling pathways in cancer cells, where AMPK serves as an upstream regulator of SRC activation 6. Due to its important role in oncogenic processes, SRC represents a promising therapeutic target for cancer treatment 47.