FBP2 (fructose-bisphosphatase 2) is a rate-limiting enzyme in gluconeogenesis that catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate 1. The enzyme functions as a tumor suppressor that is frequently downregulated in various cancers through promoter hypermethylation mediated by DNA methyltransferase 3a (DNMT3a) 2. In gastric cancer, low FBP2 expression correlates with adverse clinicopathological characteristics and poor prognosis 1. Mechanistically, FBP2 suppresses malignant progression by inhibiting glycolysis and promoting oxidative phosphorylation, while also downregulating oncogenic transcription factor c-Myc in oral squamous cell carcinoma 3. The protein is subject to post-translational regulation through ubiquitin-mediated degradation by TRIM32, an E3 ubiquitin ligase that promotes tumor progression by enhancing FBP2 degradation 4. FBP2 expression can be modulated by circular RNAs, with hsa_circ_0026344 upregulating FBP2 through competitive binding with miR-1290 5. Additionally, FBP2 has been identified as a potential biomarker for traditional Mongolian medicine symptom evaluation in viral infectious diseases 6. These findings establish FBP2 as a metabolic tumor suppressor with significant clinical implications for cancer diagnosis and treatment.