FGF11 (fibroblast growth factor 11) is a member of the FGF11 subfamily, also known as fibroblast growth factor homologous factors (FHFs), which are functionally distinct from classical FGF receptor-binding FGFs 1. Unlike canonical FGFs, FGF11 lacks a signal peptide and functions primarily as an intracellular protein, though recent evidence suggests it can be secreted 23. The protein exists in two main isoforms (FGF11a and FGF11b) formed by alternative splicing, with distinct cellular localizations in both cytoplasm and nucleus 43. FGF11 is prominently expressed in developing and mature neurons of the central and peripheral nervous systems, as well as in the heart, with expression persisting into adult tissues 1. The protein demonstrates versatile functionality, interacting with MAPK scaffolding proteins, stabilizing microtubules, and binding voltage-gated sodium channels 1. In disease contexts, FGF11 shows pathological relevance in neurological disorders, with mutant mouse lines displaying various neurological pathologies and the gene being considered a candidate for X-linked neurological diseases 1. Additionally, FGF11 plays roles in bone resorption through hypoxia-induced osteoclast activation 5 and serves as a prognostic biomarker in HPV-positive oropharyngeal squamous cell carcinoma 6.