NAV2 (neuron navigator 2) is a multifunctional protein that plays critical roles in neuronal development and cytoskeletal organization. The protein is highly expressed in brain tissue and is essential for nervous system development 1. NAV2 functions in neurite outgrowth, particularly in response to all-trans retinoic acid stimulation, and interacts with 14-3-3ε to regulate axon elongation 2. The gene shows significant downregulation during chondrocyte differentiation in growth plates, suggesting involvement in height regulation 3. Genetic variants in NAV2 have been associated with Alzheimer's disease risk and age of onset through family-based studies 1. In cancer contexts, NAV2 participates in chr11 translocations with TCF7L1 in colorectal carcinoma and is enriched in hepatocyte-derived exosomes that promote liver metastasis 45. The NAV2 antisense RNA (NAV2-AS2) regulates cardiovascular pathology by forming RNA duplexes with NAV2 mRNA to enhance protein stability, thereby modulating endothelial-to-mesenchymal transition and cardiac fibrosis 67. NAV2 expression is also responsive to dexamethasone treatment in corneal fibroblasts, indicating broader roles in inflammatory responses 8.