FGF7 (fibroblast growth factor 7) is a paracrine signaling molecule that plays crucial roles in cell proliferation, differentiation, and tissue regeneration across multiple organ systems. FGF7 primarily functions through binding to fibroblast growth factor receptors, particularly FGFR1 and FGFR2, activating downstream MEK1/2-ERK1/2 signaling pathways 1. In skeletal muscle, FGF7 is secreted by fibro-adipogenic progenitors and promotes muscle satellite cell proliferation via FGFR2, enhancing muscle regeneration and counteracting age-related myopathy 2. The protein demonstrates tissue-specific functions, promoting eccrine sweat gland development when combined with FGF10 1, and supporting tendon healing through enhanced tenocyte proliferation and anti-apoptotic effects 3. In cancer contexts, FGF7 exhibits dual roles: it contributes to cancer-associated fibroblast-mediated tumor protection in lung cancer 4 and correlates with gastric cancer progression in H. pylori infections 5. Additionally, FGF7 shows contrasting effects in bone metabolism, protecting against osteoporosis while potentially exacerbating osteoarthritis progression 6. The protein also promotes hair growth by enhancing relevant gene expression 7, highlighting its diverse therapeutic potential across multiple tissue types and disease contexts.