FGFR1OP2 (FGFR1 oncogene partner 2) is a cytoskeleton-associated scaffolding protein with dual roles in wound healing and oncogenic signaling. Primary function: FGFR1OP2/wit3.0 facilitates fibroblast-driven wound closure through cytoskeleton organization and cell migration 1. The protein forms dimers and oligomers via coiled-coil structures and associates with cytoskeleton networks 1. Overexpression increases collagen gel contraction in oral fibroblasts, while knockdown attenuates this response 1. Mechanism: FGFR1OP2 regulates cell motility independently of myofibroblast differentiation markers or TGF-β1 signaling 1. It functions as a STRIPAK complex component, organizing signaling complexes involved in cell migration and polarity 2. Disease relevance: FGFR1OP2 participates in chr12 translocations fused to FGFR1 in 8p11 myeloproliferative syndrome, creating HSP90-dependent oncoproteins with constitutive tyrosine kinase activity 34. Additionally, genetic polymorphisms in FGFR1OP2 associate with excessive mandibular bone atrophy following dental extraction, potentially through abnormal oral mucosa contraction 56. Clinical significance: FGFR1OP2 represents a therapeutic target for both wound management acceleration 1 and HSP90-inhibitor-based treatment of FGFR1-fusion leukemias 4.