FGFRL1 is a fibroblast growth factor receptor-like protein that functions as a multifunctional regulator of cell growth and development. Unlike classical FGFRs, FGFRL1 lacks an intracellular tyrosine kinase domain but retains an extracellular domain that binds FGF ligands and heparin with high affinity 1. It exerts a negative effect on cell proliferation while promoting cell differentiation 1. FGFRL1 plays essential roles in prenatal and postnatal development, particularly in cartilage and bone formation, kidney development, and diaphragm development 21. Functionally, FGFRL1 operates as a modulator of FGF signaling and participates in cell-cell adhesion and transport vesicle functions 1. The protein contains a histidine-rich intracellular motif enabling alternative signaling mechanisms 1. Clinically, FGFRL1 dysfunction contributes to multiple human diseases. Germline mutations cause congenital abnormalities including craniosynostosis and kidney agenesis 1. Genetic variants in FGFRL1 are associated with height determination, hypertension, and osteoporosis 3. Recent evidence indicates FGFRL1 as a potential therapeutic target for migraine 45 and a comorbid gene in neurodegenerative diseases including amyotrophic lateral sclerosis and Parkinson's disease 6. Additionally, FGFRL1 is aberrantly upregulated in esophageal cancer and regulated by miR-107 7.