VEZT (vezatin) is a transmembrane protein of adherens junctions with multiple biological roles. Primary function involves cell-cell adhesion at plasma membranes and organization of the stereocilia ankle link complex 1. Additionally, VEZT regulates retrograde axonal transport as a conserved cargo-specific regulator, particularly for endosomes and dense core vesicles but not mitochondria 2. Mechanistically, VEZT expression is regulated by promoter methylation and microRNA-43c in cancer contexts 3. Loss of VEZT expression through hypermethylation occurs in gastric cancer and correlates with disease progression 45. When restored, VEZT suppresses cell growth and tumorigenicity by regulating downstream targets including GPR56, CDC42, and TCF19 4. Disease relevance spans multiple conditions. In Usher syndrome, VEZT is a candidate gene for inherited hearing loss and retinitis pigmentosa 1. In gastric cancer, reduced VEZT expression associates with increased lymphatic metastasis, deeper invasion, and poor prognosis, suggesting tumor suppressor function 5. In endometriosis, VEZT variants (rs10859871) show strong cis-expression quantitative trait locus effects, with risk alleles associated with increased expression 678. Clinically, VEZT expression levels serve as an independent prognostic biomarker in gastric cancer, with strong expression predicting longer survival 5.