FLNA (filamin A) is an X-linked actin-binding protein that serves as a critical scaffolding molecule linking the actin cytoskeleton to membrane proteins and facilitating cellular signaling 1. The protein plays essential roles in neurodevelopment, particularly in neuronal migration and brain organization, with mutations causing periventricular nodular heterotopia and other neurodevelopmental disorders 21. FLNA functions as a key regulator of cardiovascular development and remodeling, with mutations associated with cardiac valvular dysplasia, aortic stenosis, and vascular malformations 34. In pathological contexts, FLNA contributes to disease progression through multiple mechanisms: it promotes pathological angiogenesis in moyamoya disease via AKT/GSK-3β/β-catenin signaling 5, modulates tumor immunity and metastasis in colorectal cancer through disulfidptosis regulation 6, and drives seizure activity in focal cortical malformations 7. Therapeutically, FLNA represents a promising target, with small molecule inhibitor PTI-125 showing efficacy in reducing seizures and tumor progression 76. The protein's involvement spans from developmental biology to cancer and neurological diseases, highlighting its fundamental importance in cellular organization and disease pathogenesis.