FOXF2 is a forkhead box transcription factor that functions as a sequence-specific DNA-binding transcriptional activator 1. It regulates lung-specific gene expression and mediates ubiquitination and degradation of CTNNB1 through upregulation of the E3 ligase IRF2BPL. FOXF2 maintains endothelial cell function via Tie2 signaling activation 2, critical for blood-brain barrier integrity and cerebrovascular homeostasis. The gene regulates extracellular matrix-related genes and collagen I production in scar fibroblasts, suggesting a role in scar maintenance 3. In cancer, FOXF2 exhibits context-dependent roles: it promotes breast cancer metastasis to bone through NF-κB and BMP pathway activation, while suppressing lung metastasis via TGFβ repression 4. In bladder cancer, FOXF2 acts as a tumor suppressor, with miR-182-5p-mediated downregulation promoting cancer progression through SHH pathway activation 5. FOXF2 is associated with cerebral small vessel disease and lacunar stroke risk through pericyte differentiation regulation 62. Its aberrant expression contributes to multiple pathological processes including proliferation, invasion, and metastasis across different cancer types 78. FOXF2 emerges as both a potential therapeutic target and biomarker for cancer diagnosis and prognosis.